BUILT ON RESEARCH. DRIVEN BY IMPACT.

    Enhancing Care Foundation (ECF) is a South African not-for-profit organisation delivering health system strengthening, capacity building, and clinical and non-clinical research services. With deep experience managing NIH-funded clinical trials in HIV and TB — and a leadership team that has independently retained both a Paediatric and an Adult AIDS Clinical Trials Unit (ACTU) since 2007 — we bring a multi-national, collaborative team that implements studies with exceptional scientific rigour within the local context.

    • HIV & TB research focus
    • Paediatric & Adult ACTU since 2007
    • Widely published leadership
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    Scientific Rigour First

    We hold every study to the highest scientific and ethical standards, delivering research that is credible, compliant, and trusted by funders and partners.

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    Research Excellence

    Our work is carried out by an experienced, widely published, multi-national team committed to quality, accuracy, and meaningful results.

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    Reliable Delivery

    We manage complex, multi-year clinical trials with discipline and care — delivering on our commitments to participants, funders, and communities.

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    OUR COVERAGE

    We operate across 3 sites, Victoria Mxenge Hospital, Wentworth Hospital and Mount Edgecombe.

    Mount Edgecombe Research Centre
    The headquarters of ECF, serving as the administrative, regulatory, and operational hub supporting clinical research activities.

    Victoria Mxenge Hospital Research Unit
    A comprehensive clinical research facility equipped with data management capabilities, satellite pharmacy services, and specialised trial implementation teams.

    Wentworth Hospital Research Site
    An outpatient and inpatient clinical research facility supporting complex studies, participant follow-up, and clinical care.

    Clinical & Non-Clinical Research

    We design and manage clinical and non-clinical research, including NIH-funded HIV and TB trials, delivered with exceptional scientific rigour.

    Capacity Building

    We grow skills, systems and linkages — increasing research capacity and ensuring quality of work across teams and partners.

    Health System Strengthening

    We strengthen existing health systems and improve the research environment to deliver better outcomes at scale.

    ADVANCING RESEARCH. ENHANCING CARE.

    From rigorous clinical research to capacity building and stronger health systems. Whether you’re a funder, researcher, or partner organisation, we’re ready to collaborate on work that improves health and well-being.
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    BUILT ON RIGOUR. TRUSTED FOR RESULTS.

    Delivering research that stands up to scrutiny.

    Proven Research Experience

    Extensive experience managing NIH-funded clinical trials in HIV and TB, backed by a widely published leadership team.

    Ethical & Compliant

    Every study is conducted to rigorous ethical and regulatory standards, ensuring credible, trusted results.

    Scientific Rigour

    We implement studies with exceptional scientific rigour, grounded in the local context.

    Reliable Delivery

    We manage complex, multi-year trials with discipline — meeting commitments to participants and funders.

    Collaborative Team

    A multi-national, collaborative team working in partnership across institutions and borders.

    Capacity-Focused Approach

    We build skills, systems and linkages that strengthen research and care well beyond any single study.

    Advancing Science. Strengthening Communities. Transforming Lives.

    The Enhancing Care Foundation (ECF) is a South African clinical research organisation committed to advancing scientific knowledge, strengthening health systems, and improving health outcomes. Through innovative research, strategic partnerships, and meaningful community engagement, we generate evidence that informs healthcare policy, clinical practice, and programme implementation locally and globally.
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    Rigorous & Credible

    Research designed and delivered to the highest scientific and ethical standards.

    Collaborative by Design

    A multi-national team working in partnership with leading institutions.

    Real-World Impact

    Work focused on strengthening health systems and improving care across Africa and beyond.

    Built for Rigour and Impact

    We deliver clinical and non-clinical research, capacity building, and health system strengthening designed to improve outcomes in HIV/AIDS, TB and related conditions. Our work is built for scientific rigour, ethics, and long-term impact — ensuring lasting benefit across the communities and systems we serve.

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